Dr. Anna May

Dr. Anna May is the protector of all things anime and the guardian of virginity, she fights Scott Wozniak because he "doesn't give a shit about anime", she appears in Episode 151: Anime Games. She is voiced by Kristi Rothrock and animated by Channy and Kimberly.

In Anime Games
At the end when Scott Wozniak is talking about how he doesn't understand anime, a portal appears and Scott Wozniak immediately enters it, here he meets Dr. Anna May who tries to kill him because he "doesn't give a shit about anime", at the start she has the upper hand, but then Scott Wozniak uses his humiliation and summons three anime games, two copies of Dragon Ball Z: Budokai Tenkaichi 3 and one copy of Tokyo Mirage Sessions ♯FE.

After fighting for a while, Dr. Anna May kicks Scott Wozniak out of the robot he created to fight her using psychokinesis and heavily hits Scott Wozniak, however, Scott Wozniak manages to beat her by hitting her with a copy of Mighty No. 9.

Trivia

 * Her name is presumably a play on the word anime.
 * Her way of getting killed in Anime Games is similar to how the Genesis Mech was defeated in It's Awesome Baby!
 * She is referenced in Borderline Forever, when Scott Wozniak sees a memory of him fighting her while trying to find the blue border, to which he notices it was there as well.